Oxidative Stress Induced by a Dihydropyrazine Derivative

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Oxidative stress induced by a dihydropyrazine derivative.

The Maillard reaction contributes to the complications of diabetes and normal aging. Dihydropyrazines (DHPs), which are produced during the Maillard reaction, generate radicals and possess DNA strand-cleaving activities in vitro. In the present study, we evaluated the genotoxic and cytotoxic potentials of a DHP derivative, cyclohexyl-DHP, which is obtained as a mixture of two isomers, 2,3,5,6,7...

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ژورنال

عنوان ژورنال: Biological and Pharmaceutical Bulletin

سال: 2009

ISSN: 0918-6158,1347-5215

DOI: 10.1248/bpb.32.186